Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells

• Autori principali: Anna Mieszkowska (Autore), Anna M. Nowicka (Autore), Agata Kowalczyk (Autore), Agnieszka Potęga (Autore), Monika Pawłowska (Autore), Michał Kosno (Autore), Ewa Augustin (Autore), Zofia Mazerska (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

New unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude mice. Representative UA compounds, named C-2028, C-2045 and C-2053, were characterized in respect to their physicochemical properties and the fol...