Activation of Nrf2 by Electrophiles Is Largely Independent of the Selenium Status of HepG2 Cells

• Main Authors: Sarah Tauber (Author), Maria Katharina Sieckmann (Author), Katrin Erler (Author), Wilhelm Stahl (Author), Lars-Oliver Klotz (Author), Holger Steinbrenner (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Selenoenzymes, whose activity depends on adequate selenium (Se) supply, and phase II enzymes, encoded by target genes of nuclear factor erythroid 2-related factor 2 (Nrf2), take part in governing cellular redox homeostasis. Their interplay is still not entirely understood. Here, we exposed HepG2 hep...