Development of α-Cyclodextrin-Based Orally Disintegrating Tablets for 4-Phenylbutyrate

• Main Authors: Kindness L. Commey (Author), Airi Enaka (Author), Ryota Nakamura (Author), Asami Yamamoto (Author), Kenji Tsukigawa (Author), Koji Nishi (Author), Daisuke Iohara (Author), Fumitoshi Hirayama (Author), Masaki Otagiri (Author), Keishi Yamasaki (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Despite major improvements brought about by the introduction of taste-masked formulations of 4-phenylbutyrate (PB), poor compliance remains a significant drawback to treatment for some pediatric and dysphagic patients with urea cycle disorders (UCDs). This study reports on the development of a cyclo...