New benzothiazole hybrids as potential VEGFR-2 inhibitors: design, synthesis, anticancer evaluation, and in silico study

• Main Authors: Mohammad M. Al-Sanea (Author), Abdelrahman Hamdi (Author), Ahmed A. B. Mohamed (Author), Hamed W. El-Shafey (Author), Mahmoud Moustafa (Author), Abdullah A. Elgazar (Author), Wagdy M. Eldehna (Author), Hidayat Ur Rahman (Author), Della G. T. Parambi (Author), Rehab M. Elbargisy (Author), Samy Selim (Author), Syed Nasir Abbas Bukhari (Author), Omnia Magdy Hendawy (Author), Samar S. Tawfik (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of 2-aminobenzothiazole hybrids linked to thiazolidine-2,4-dione 4a-e, 1,3,4-thiadiazole aryl urea 6a-d, and cyanothiouracil moieties 8a-d was synthesised. The in vitro antitumor effect of the new hybrids was assessed against three cancer cell lines, namely, HCT-116, HEPG-2, and MCF-7 u...