Poloxamer 407-induced atherosclerosis in mice appears to be due to lipid derangements and not due to its direct effects on endothelial cells and macrophages

• Main Authors: Thomas P. Johnston (Author), Yuai Li (Author), Ahmed S. Jamal (Author), Daniel J. Stechschulte (Author), Kottarappat N. Dileepan (Author)
• Format: Book
• Published: Hindawi Limited, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coronary heart disease secondary to atherosclerosis is still the leading cause of death in the US. Animal models used for elucidating the pathogenesis of this disease primarily involve rabbits and pigs. Previous studies from this laboratory have demonstrated intraperitoneal injections of poloxamer 4...