Radiosynthesis and in vivo evaluation of 11C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors

• Main Authors: Kazunori Kawamura (Author), Wakana Mori (Author), Masayuki Fujinaga (Author), Tomoteru Yamasaki (Author), Yiding Zhang (Author), Hidekatsu Wakizaka (Author), Akiko Hatori (Author), Lin Xie (Author), Katsushi Kumata (Author), Takayuki Ohkubo (Author), Yusuke Kurihara (Author), Masanao Ogawa (Author), Nobuki Nengaki (Author), Ming-Rong Zhang (Author)
• Format: Book
• Published: SpringerOpen, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Neuropeptide Y (NPY) has been implicated in a wide variety of physiological processes, including feeding, learning, memory, emotion, cardiovascular homeostasis, hormone secretion, and circadian rhythms. NPY Yl receptor (NPY Y1-R) is the most widely studied NPY receptor, and is in...