Treatment of severe COVID-19 patients with either low- or high-volume of convalescent plasma versus standard of care: A multicenter Bayesian randomized open-label clinical trial (COOP-COVID-19-MCTI)

• Автори: Alice T.W. Song (Автор), Vanderson Rocha (Автор), Alfredo Mendrone-Júnior (Автор), Rodrigo T. Calado (Автор), Gil C. De Santis (Автор), Bruno D. Benites (Автор), Carolina Costa-Lima (Автор), Taiani Vargas (Автор), Leonardo S. Marques (Автор), Juliana C. Fernandes (Автор), Felipe C. Breda (Автор), Silvano Wendel (Автор), Roberta Fachini (Автор), Luiz V. Rizzo (Автор), José Mauro Kutner (Автор), Vivian I. Avelino-Silva (Автор), Rafael R.G. Machado (Автор), Edison L. Durigon (Автор), Sylvie Chevret (Автор), Esper G. Kallas (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2022-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Summary: Background: Administration of convalescent plasma may serve as an adjunct to supportive treatment to prevent COVID-19 progression and death. We aimed to evaluate the efficacy and safety of 2 volumes of intravenous convalescent plasma (CP) with high antibody titers for the treatment of sever...