PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis

Objective: In the hypothalamic arcuate nucleus (ARC), orexigenic agouti-related peptide (AgRP) neurons regulate feeding behavior and energy homeostasis, functions connected to bone metabolism. The 3-phosphoinositide-dependent protein kinase-1 (PDK1) serves as a major signaling molecule particularly...

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Main Authors: Hideyuki Sasanuma (Author), Masanori Nakata (Author), Kumari Parmila (Author), Jun Nakae (Author), Toshihiko Yada (Author)
Format: Book
Published: Elsevier, 2017-05-01T00:00:00Z.
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