Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling

Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling

In the heart, ageing is associated with DNA damage, oxidative stress, fibrosis and activation of the activin signalling pathway, leading to cardiac dysfunction. The cardiac effects of activin signalling blockade in progeria are unknown. This study investigated the cardiac effects of progeria induced...

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Main Authors: Nicolas G. Clavere (Author), Ali Alqallaf (Author), Kerry A. Rostron (Author), Andrew Parnell (Author), Robert Mitchell (Author), Ketan Patel (Author), Samuel Y. Boateng (Author)
Format: Book
Published: The Company of Biologists, 2022-05-01T00:00:00Z.
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