Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling

• Главные авторы: Nicolas G. Clavere (Автор), Ali Alqallaf (Автор), Kerry A. Rostron (Автор), Andrew Parnell (Автор), Robert Mitchell (Автор), Ketan Patel (Автор), Samuel Y. Boateng (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2022-05-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

In the heart, ageing is associated with DNA damage, oxidative stress, fibrosis and activation of the activin signalling pathway, leading to cardiac dysfunction. The cardiac effects of activin signalling blockade in progeria are unknown. This study investigated the cardiac effects of progeria induced...