Limited Sampling Strategy for the Estimation of Mycophenolic Acid and its Acyl Glucuronide Metabolite Area under the Concentration-Time Curve in Japanese Lung Transplant Recipients

• Main Authors: Masaki Tanaka (Author), Masafumi Kikuchi (Author), Shinya Takasaki (Author), Tensei Hirasawa (Author), Kensuke Sigeta (Author), Aoi Noda (Author), Miki Akiba (Author), Yasushi Matsuda (Author), Hisashi Oishi (Author), Tetsu Sado (Author), Masafumi Noda (Author), Yoshinori Okada (Author), Nariyasu Mano (Author), Hiroaki Yamaguchi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: The dose of mycophenolate mofetil (MMF) used to prevent rejection after lung transplantation is often adjusted based on the 12-hour area under the concentration-time curve (AUC0-12) of mycophenolic acid (MPA). A limited sampling strategy (LSS) is useful to define the pharmacokinetic (PK) pr...