Analysis of MEFV exon methylation and expression patterns in familial Mediterranean fever

• Main Authors: Ozdogan Huri (Author), Hatemi Gulen (Author), Celikyapi Erdem Gokce (Author), Arisoy Nil (Author), Kasapcopur Ozgur (Author), Kirectepe Asli K (Author), Tahir Turanli Eda (Author)
• Format: Book
• Published: BMC, 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>MEFV mutations and decreased expression level of the gene are related to FMF pathology. DNA methylation at CpG islands is a well-known mechanism for transcriptional silencing. MEFV has a CpG island, spanning a part of the first intro...