A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114

• Autori principali: Hikari Araki (Autore), Toru Takenaka (Autore), Koichi Takahashi (Autore), Fumiaki Yamashita (Autore), Kazuaki Matsuoka (Autore), Kunihiro Yoshisue (Autore), Ichiro Ieiri (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2022-05-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract TAS‐114 is a dual deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD) inhibitor expected to widen the therapeutic index of capecitabine. Its maximum tolerated dose (MTD) was determined from a safety perspective in a combination study with capecitabine; however, i...