A semimechanistic population pharmacokinetic and pharmacodynamic model incorporating autoinduction for the dose justification of TAS‐114

• Main Authors: Hikari Araki (Author), Toru Takenaka (Author), Koichi Takahashi (Author), Fumiaki Yamashita (Author), Kazuaki Matsuoka (Author), Kunihiro Yoshisue (Author), Ichiro Ieiri (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract TAS‐114 is a dual deoxyuridine triphosphatase (dUTPase) and dihydropyrimidine dehydrogenase (DPD) inhibitor expected to widen the therapeutic index of capecitabine. Its maximum tolerated dose (MTD) was determined from a safety perspective in a combination study with capecitabine; however, i...