Physicochemical characterization and solubility enhancement studies of allopurinol solid dispersions

• Main Authors: Jagdale Swati Changdeo (Author), Musale Vinod (Author), Kuchekar Bhanudas Shankar (Author), Chabukswar Anuruddha Rajaram (Author)
• Formato: Livro
• Publicado em: Universidade de São Paulo, 2011-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Allopurinol is a commonly used drug in the treatment of chronic gout or hyperuricaemia associated with treatment of diuretic conditions. One of the major problems with the drug is that it is practically insoluble in water, which results in poor bioavailability after oral administration. In the prese...