Optimizing gentamicin conventional and extended interval dosing in neonates using Monte Carlo simulation - a retrospective study

• Main Authors: Monique Bergenwall (Author), Sandra A. N. Walker (Author), Marion Elligsen (Author), Dolores C. Iaboni (Author), Carla Findlater (Author), Winnie Seto (Author), Eugene Ng (Author)
• Format: Book
• Published: BMC, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Although aminoglycosides are routinely used in neonates, controversy exists regarding empiric dosing regimens. The objectives were to determine gentamicin pharmacokinetics in neonates, and develop initial mg/kg dosing recommendations that optimized target peak and trough concentr...