IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells

• Main Authors: Zhe Wang (Author), Guangyan Liu (Author), Jiwei Mao (Author), Min Xie (Author), Ming Zhao (Author), Xuefen Guo (Author), Shanshan Liang (Author), Heming Li (Author), Xuefeng Li (Author), Ruoyu Wang (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although ionizing radiation (IR) has provided considerable improvements in nasopharyngeal carcinoma (NPC) treatment, radioresistance is still a major threat for some subsets of patients. The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is tightly regulated and plays critical role...