Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure

• Главные авторы: Christian Siebel (Автор), Gudrun Würthwein (Автор), Claudia Lanvers-Kaminsky (Автор), Nicolas André (Автор), Frank Berthold (Автор), Ilaria Castelli (Автор), Pascal Chastagner (Автор), François Doz (Автор), Martin English (Автор), Gabriele Escherich (Автор), Michael C. Frühwald (Автор), Norbert Graf (Автор), Andreas H. Groll (Автор), Antonio Ruggiero (Автор), Georg Hempel (Автор), Joachim Boos (Автор)
• Формат: ‌
• Опубликовано: BMC, 2020-05-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract Background Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particu...