Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure

• Main Authors: Christian Siebel (Author), Gudrun Würthwein (Author), Claudia Lanvers-Kaminsky (Author), Nicolas André (Author), Frank Berthold (Author), Ilaria Castelli (Author), Pascal Chastagner (Author), François Doz (Author), Martin English (Author), Gabriele Escherich (Author), Michael C. Frühwald (Author), Norbert Graf (Author), Andreas H. Groll (Author), Antonio Ruggiero (Author), Georg Hempel (Author), Joachim Boos (Author)
• Format: Book
• Published: BMC, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as treatment strategies vary and do not follow a clear pharmacological rationale. Standardisation of dosing strategies in particu...