Dissolving microneedles for DNA vaccination: Improving functionality via polymer characterization and RALA complexation

• Main Authors: Grace Cole (Author), Joanne McCaffrey (Author), Ahlam A. Ali (Author), John W. McBride (Author), Cian M. McCrudden (Author), Eva M. Vincente-Perez (Author), Ryan F. Donnelly (Author), Helen O. McCarthy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA vaccination holds the potential to treat or prevent nearly any immunogenic disease, including cancer. To date, these vaccines have demonstrated limited immunogenicity in vivo due to the absence of a suitable delivery system which can protect DNA from degradation and improve transfection efficien...