Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication

• Main Authors: Meng-Hao Huang (Author), Hu Li (Author), Rong Xue (Author), Jianrui Li (Author), Lihua Wang (Author), Junjun Cheng (Author), Zhouyi Wu (Author), Wenjing Li (Author), Jinhua Chen (Author), Xiaoqin Lv (Author), Qiang Li (Author), Pei Lan (Author), Limin Zhao (Author), Yongfeng Yang (Author), Zonggen Peng (Author), Jiandong Jiang (Author)
• Format: Book
• Published: Elsevier, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bicyclol is a synthetic drug for hepatoprotection in clinic since 2004. Preliminary clinical observations suggest that bicyclol might be active against hepatitis C virus (HCV) with unknown mechanism. Here, we showed that bicyclol significantly inhibited HCV replication in vitro and in hepatitis C pa...