A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats

• Main Authors: Soojin Kim (Author), Seunghyun Lee (Author), Hanju Lee (Author), Sanghyun Ju (Author), Sohee Park (Author), Doyoung Kwon (Author), Jin-Wook Yoo (Author), In-Soo Yoon (Author), Do Sik Min (Author), Young-Suk Jung (Author), Yunjin Jung (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An elevated level of endoplasmic reticulum (ER) stress is considered an aggravating factor for inflammatory bowel disease (IBD). To develop an ER-stress attenuator that is effective against colitis, 4-phenylbutyric acid (4-PBA), a chemical chaperone that alleviates ER stress, was conjugated with aci...