Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice

• Main Authors: Lilliana Beck (Author), Estéfano Pinilla (Author), Daniel Dias Rufino Arcanjo (Author), Raquel Hernanz (Author), Judit Prat-Duran (Author), Asbjørn Graver Petersen (Author), Ralf Köhler (Author), Majid Sheykhzade (Author), Simon Comerma-Steffensen (Author), Ulf Simonsen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Therefore, in a first study we investigated the mechan...