Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice

• প্রধান লেখক: Lilliana Beck (লেখক), Estéfano Pinilla (লেখক), Daniel Dias Rufino Arcanjo (লেখক), Raquel Hernanz (লেখক), Judit Prat-Duran (লেখক), Asbjørn Graver Petersen (লেখক), Ralf Köhler (লেখক), Majid Sheykhzade (লেখক), Simon Comerma-Steffensen (লেখক), Ulf Simonsen (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Therefore, in a first study we investigated the mechan...