Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice

• Hoofdauteurs: Lilliana Beck (Auteur), Estéfano Pinilla (Auteur), Daniel Dias Rufino Arcanjo (Auteur), Raquel Hernanz (Auteur), Judit Prat-Duran (Auteur), Asbjørn Graver Petersen (Auteur), Ralf Köhler (Auteur), Majid Sheykhzade (Auteur), Simon Comerma-Steffensen (Auteur), Ulf Simonsen (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Endothelial cell dysfunction and fibrosis are associated with worsening of the prognosis in patients with cardiovascular disease. Pirfenidone has a direct antifibrotic effect, but vasodilatation may also contribute to the effects of pirfenidone. Therefore, in a first study we investigated the mechan...