Role of efficacy as a determinant of locomotor activation by mu‐opioid receptor (MOR) ligands in female and male mice. II. Effects of novel MOR‐selective phenylmorphans with high‐to‐low MOR efficacy

• Main Authors: Edna J. Santos (Author), Nima Nassehi (Author), Eric W. Bow (Author), Dana R. Chambers (Author), Eugene S. Gutman (Author), Arthur E. Jacobson (Author), Joshua A. Lutz (Author), Samuel A. Marsh (Author), Kenner C. Rice (Author), Agnieszka Sulima (Author), Dana E. Selley (Author), S. Stevens Negus (Author)
• Format: Book
• Published: Wiley, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Low‐efficacy mu‐opioid receptor (MOR) agonists represent promising therapeutics, but existing compounds (e.g., buprenorphine, nalbuphine) span a limited range of low MOR efficacies and have poor MOR selectivity. Accordingly, new and selective low‐efficacy MOR agonists are of interest. A nov...