A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects

• Автори: Sibel Ucpinar (Автор), Borje Darpo (Автор), Ann Neale (Автор), Philip Nunn (Автор), Jin Shu (Автор), Katherine A. Chu (Автор), Marianne Kavanagh (Автор), Hongqi Xue (Автор), Pasit Phiasivongsa (Автор), Dolca Thomas (Автор), Patrick F. Smith (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2022-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract This study aimed to define the clinically relevant supratherapeutic dose of rilzabrutinib, an oral Bruton tyrosine kinase (BTK) inhibitor, and evaluate potential effects of therapeutic and supratherapeutic exposures on cardiac repolarization in healthy subjects. This was a two‐part phase I...