Development of a fluorogenic ADAMTS-7 substrate

• Main Authors: Salvatore Santamaria (Author), Frederic Buemi (Author), Elisa Nuti (Author), Doretta Cuffaro (Author), Elena De Vita (Author), Tiziano Tuccinardi (Author), Armando Rossello (Author), Steven Howell (Author), Shahid Mehmood (Author), Ambrosius P. Snijders (Author), Rens de Groot (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The extracellular protease ADAMTS-7 has been identified as a potential therapeutic target in atherosclerosis and associated diseases such as coronary artery disease (CAD). However, ADAMTS-7 inhibitors have not been reported so far. Screening of inhibitors has been hindered by the lack of a suitable...