Enhanced insulin sensitivity in skeletal muscle and liver by physiological overexpression of SIRT6

• Main Authors: Jason G. Anderson (Author), Giorgio Ramadori (Author), Rafael M. Ioris (Author), Mirco Galiè (Author), Eric D. Berglund (Author), Katie C. Coate (Author), Teppei Fujikawa (Author), Stefania Pucciarelli (Author), Benedetta Moreschini (Author), Augusto Amici (Author), Cristina Andreani (Author), Roberto Coppari (Author)
• Format: Book
• Published: Elsevier, 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Available treatment for obesity and type 2 diabetes mellitus (T2DM) is suboptimal. Thus, identifying novel molecular target(s) exerting protective effects against these metabolic imbalances is of enormous medical significance. Sirt6 loss- and gain-of-function studies have generated confou...