Identification of strain-specific B-cell epitopes in Trypanosoma cruzi using genome-scale epitope prediction and high-throughput immunoscreening with peptide arrays.

• Main Authors: Tiago Antônio de Oliveira Mendes (Author), João Luís Reis Cunha (Author), Rodrigo de Almeida Lourdes (Author), Gabriela Flávia Rodrigues Luiz (Author), Lucas Dhom Lemos (Author), Ana Rita Rocha dos Santos (Author), Antônia Cláudia Jácome da Câmara (Author), Lúcia Maria da Cunha Galvão (Author), Caryn Bern (Author), Robert H Gilman (Author), Ricardo Toshio Fujiwara (Author), Ricardo Tostes Gazzinelli (Author), Daniella Castanheira Bartholomeu (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The factors influencing variation in the clinical forms of Chagas disease have not been elucidated; however, it is likely that the genetics of both the host and the parasite are involved. Several studies have attempted to correlate the T. cruzi strains involved in infection with the clin...