Case report: Revascularization failure in NF1-related moyamoya syndrome after selumetinib: A possible pathophysiological correlation?

• Main Authors: Cristina Chelleri (Author), Marcello Scala (Author), Patrizia De Marco (Author), Monica Traverso (Author), Marzia Ognibene (Author), Irene Bruno (Author), Gianluca Piccolo (Author), Pasquale Striano (Author), Mariasavina Severino (Author), Federico Zara (Author), Maria Cristina Diana (Author), Marco Pavanello (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurofibromatosis type 1 (NF1) is a neurocutaneous syndrome caused by pathogenic variants in the NF1 gene, encoding a multidomain inhibitor of Ras activity. Thus, NF1 is considered a RASopathy and drugs targeting the RAS/mitogen-activated protein kinase (MAPK) pathway, such as the MAP kinase (MEK) 1...