Individualized dosing parameters for tacrolimus in the presence of voriconazole: a real-world PopPK study

• Main Authors: Yi-Chang Zhao (Author), Zhi-Hua Sun (Author), Jia-Kai Li (Author), Huai-Yuan Liu (Author), Bi-Kui Zhang (Author), Xu-Biao Xie (Author), Chun-Hua Fang (Author), Indy Sandaradura (Author), Feng-Hua Peng (Author), Miao Yan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectivesSignificant increase in tacrolimus exposure was observed during co-administration with voriconazole, and no population pharmacokinetic model exists for tacrolimus in renal transplant recipients receiving voriconazole. To achieve target tacrolimus concentrations, an optimal dosage regimen i...