Individualized dosing parameters for tacrolimus in the presence of voriconazole: a real-world PopPK study

• Autors principals: Yi-Chang Zhao (Autor), Zhi-Hua Sun (Autor), Jia-Kai Li (Autor), Huai-Yuan Liu (Autor), Bi-Kui Zhang (Autor), Xu-Biao Xie (Autor), Chun-Hua Fang (Autor), Indy Sandaradura (Autor), Feng-Hua Peng (Autor), Miao Yan (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

ObjectivesSignificant increase in tacrolimus exposure was observed during co-administration with voriconazole, and no population pharmacokinetic model exists for tacrolimus in renal transplant recipients receiving voriconazole. To achieve target tacrolimus concentrations, an optimal dosage regimen i...