The rat rotenone model reproduces the abnormal pattern of central catecholamine metabolism found in Parkinson's disease

• Κύριοι συγγραφείς: Regev Landau (Συγγραφέας), Reut Halperin (Συγγραφέας), Patti Sullivan (Συγγραφέας), Zion Zibly (Συγγραφέας), Avshalom Leibowitz (Συγγραφέας), David S. Goldstein (Συγγραφέας), Yehonatan Sharabi (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: The Company of Biologists, 2022-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Recent reports indicate that Parkinson's disease (PD) involves specific functional abnormalities in residual neurons - decreased vesicular sequestration of cytoplasmic catecholamines via the vesicular monoamine transporter (VMAT) and decreased aldehyde dehydrogenase (ALDH) activity. This double...