The rat rotenone model reproduces the abnormal pattern of central catecholamine metabolism found in Parkinson's disease

• Main Authors: Regev Landau (Author), Reut Halperin (Author), Patti Sullivan (Author), Zion Zibly (Author), Avshalom Leibowitz (Author), David S. Goldstein (Author), Yehonatan Sharabi (Author)
• Format: Book
• Published: The Company of Biologists, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent reports indicate that Parkinson's disease (PD) involves specific functional abnormalities in residual neurons - decreased vesicular sequestration of cytoplasmic catecholamines via the vesicular monoamine transporter (VMAT) and decreased aldehyde dehydrogenase (ALDH) activity. This double...