Generation and testing anti-influenza human monoclonal antibodies in a new humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO. IL-2Rγc KO. NOD)

• Main Authors: Mirian Mendoza (Author), Angela Ballesteros (Author), Qi Qiu (Author), Luis Pow Sang (Author), Soumya Shashikumar (Author), Sofia Casares (Author), Teodor-D. Brumeanu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pandemic outbreaks of influenza type A viruses have resulted in numerous fatalities around the globe. Since the conventional influenza vaccines (CIV) provide less than 20% protection for individuals with weak immune system, it has been considered that broadly cross-neutralizing antibodies may provid...