Suppressive activity of macrolide antibiotics on nitric oxide production by lipopolysaccharide stimulation in mice

• Main Authors: Hajime Terao (Author), Kazuhito Asano (Author), Ken-ichi Kanai (Author), Yoshiyuki Kyo (Author), So Watanabe (Author), Tadashi Hisamitsu (Author), Harumi Suzaki (Author)
• Format: Book
• Published: Hindawi Limited, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and aim: Low-dose and long-term administration of macrolide antibiotics into patients with chronic airway inflammatory diseases could favorably modify their clinical conditions. However, the therapeutic mode of action of macrolides is not well understood. Free oxygen radicals, including n...