Impaired Resolution of Inflammation in the Endoglin Heterozygous Mouse Model of Chronic Colitis

• Main Authors: Madonna R. Peter (Author), Mirjana Jerkic (Author), Valentin Sotov (Author), David N. Douda (Author), Daniela S. Ardelean (Author), Niousha Ghamami (Author), Flavia Lakschevitz (Author), Meraj A. Khan (Author), Susan J. Robertson (Author), Michael Glogauer (Author), Dana J. Philpott (Author), Nades Palaniyar (Author), Michelle Letarte (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng+/−) mice subjected to dextran sulfate sodium (DSS) developed persistent gut inflammation and patholo...