CRISPR-cas9 screening identified lethal genes enriched in Hippo kinase pathway and of predictive significance in primary low-grade glioma

• Main Authors: Maimaitili Mijiti (Author), Aierpati Maimaiti (Author), Xiaoqing Chen (Author), Maidina Tuersun (Author), Miershayiti Dilixiati (Author), Yilidanna Dilixiati (Author), Guohua Zhu (Author), Hao Wu (Author), Yandong Li (Author), Mirzat Turhon (Author), Aimitaji Abulaiti (Author), Nuerailijiang Maimaitiaili (Author), Nadire Yiming (Author), Maimaitijiang Kasimu (Author), Yongxin Wang (Author)
• Format: Book
• Published: BMC, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Low-grade gliomas (LGG) are a type of brain tumor that can be lethal, and it is essential to identify genes that are correlated with patient prognosis. In this study, we aimed to use CRISPR-cas9 screening data to identify key signaling pathways and develop a genetic signature ass...