The beauty of symmetry: siRNA phosphorodithioate modifications reduce stereocomplexity, ease analysis, and can improve in vivo potency

• Glavni autori: Sophie Schöllkopf (Autor), Stefan Rathjen (Autor), Micaela Graglia (Autor), Nina Was (Autor), Eliot Morrison (Autor), Adrien Weingärtner (Autor), Lucas Bethge (Autor), Judith Hauptmann (Autor), Marie Wikström Lindholm (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2024-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Phosphorothioates (PSs) can be essential in stabilizing therapeutic oligonucleotides against enzymatic degradation. However, unless synthesis is performed with stereodefined amidites, each PS introduces a chemically undefined stereocenter, resulting in 2n unique molecules in the final product and af...