Medicinal chemistry advances in targeting class I histone deacetylases

• প্রধান লেখক: Diaaeldin I. Abdallah (লেখক), Elvin D. de Araujo (লেখক), Naman H. Patel (লেখক), Lina S. Hasan (লেখক), Richard Moriggl (লেখক), Oliver H. Krämer (লেখক), Patrick T. Gunning (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Open Exploration Publishing Inc., 2023-08-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gene expression at the DNA level. This tight regulation is controlled by acetylation [via histone acetyl...