Medicinal chemistry advances in targeting class I histone deacetylases

• Main Authors: Diaaeldin I. Abdallah (Author), Elvin D. de Araujo (Author), Naman H. Patel (Author), Lina S. Hasan (Author), Richard Moriggl (Author), Oliver H. Krämer (Author), Patrick T. Gunning (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gene expression at the DNA level. This tight regulation is controlled by acetylation [via histone acetyl...