Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway

• Main Authors: Xiliang Du (Author), Chiara Di Malta (Author), Zhiyuan Fang (Author), Taiyu Shen (Author), Xiaodi Niu (Author), Meng Chen (Author), Bo Jin (Author), Hao Yu (Author), Lin Lei (Author), Wenwen Gao (Author), Yuxiang Song (Author), Zhe Wang (Author), Chuang Xu (Author), Zhijun Cao (Author), Guowen Liu (Author), Xinwei Li (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and insulin resistance and there are currently no approved drugs for its treatment. Hyperactivation of mTOR complex 1 (mTORC1) and subsequent impairment of the transcription factor EB (TFEB)-mediated autophagy-lysosomal p...