A Physiologically-Based Pharmacokinetic Simulation to Evaluate Approaches to Mitigate Efavirenz-Induced Decrease in Levonorgestrel Exposure with a Contraceptive Implant

• Autores principales: Lilian W. Adeojo (Autor), Rena C. Patel (Autor), Nancy C. Sambol (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2024-08-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

<i>Background:</i> Levonorgestrel implant is a highly effective hormonal contraceptive, but its efficacy may be compromised when used with cytochrome enzyme inducers such as efavirenz. The primary aim of this study was to evaluate methods of mitigating the drug interaction. <i>Meth...