Gag and env conserved element CE DNA vaccines elicit broad cytotoxic T cell responses targeting subdominant epitopes of HIV and SIV Able to recognize virus-infected cells in macaques

• Main Authors: Xintao Hu (Author), Zhongyan Lu (Author), Antonio Valentin (Author), Margherita Rosati (Author), Kate E. Broderick (Author), Niranjan Y. Sardesai (Author), Preston A. Marx (Author), James I. Mullins (Author), George N. Pavlakis (Author), Barbara K. Felber (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HIV sequence diversity and the propensity of eliciting immunodominant responses targeting inessential variable regions are hurdles in the development of an effective AIDS vaccine. We developed a DNA vaccine comprising conserved elements (CE) of SIV p27Gag and HIV-1 Env and found that priming vaccina...