Design, synthesis, and evaluation of 4-(3-(3,5-dimethylisoxazol-4-yl)benzyl)phthalazin-1(2H)-one derivatives: potent BRD4 inhibitors with anti-breast cancer activity

• Auteurs principaux: Yingpeng Li (Auteur), Xinhong Chu (Auteur), Yu Yin (Auteur), Hongkun Li (Auteur), Hui Fu (Auteur), Xinchi Feng (Auteur), Yanru Deng (Auteur), Jun Ge (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

BRD4 inhibitors have demonstrated promising potential in cancer therapy. However, their therapeutic efficacy in breast cancer varies depending on the breast cancer subtype, particularly in the treatment of TNBC. In this study, we designed and synthesized 94 derivatives of 4-(3-(3,5-dimethylisoxazol-...