Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption

• Main Authors: Ji Yeon Park (Author), Dong Ho Oh (Author), Sang-Wook Park (Author), Bo Ram Chae (Author), Chul Woo Kim (Author), Sang Heon Han (Author), Hyeon Jong Shin (Author), Soo Bin Yeom (Author), Da Yeong Lee (Author), Min Kyu Park (Author), Sang-Eun Park (Author), Jun-Bom Park (Author), Kyung-Tae Lee (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pelubiprofen (PEL), which is a commercialized non-steroidal anti-inflammatory drug (NSAID), is associated with the risk of gastrointestinal (GI) adverse events following long-term exposure and has poor water-soluble properties. Here, a new pelubiprofen tromethamine (PEL-T) with improved solubility,...