Ultrasound‐microbubble cavitation facilitates adeno‐associated virus mediated cochlear gene transfection across the round‐window membrane

• Main Authors: Zhen Zhang (Author), Zhengnong Chen (Author), Liqiang Fan (Author), Thomas Landry (Author), Jeremy Brown (Author), Zhiping Yu (Author), Shankai Yin (Author), Jian Wang (Author)
• Format: Book
• Published: Wiley, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The round window of the cochlea provides an ideal route for delivering medicines and gene therapy reagents that can cross the round window membrane (RWM) into the inner ear. Recombinant adeno‐associated viruses (rAAVs) have several advantages and are recommended as viral vectors for gene tr...