Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells

• Main Authors: Haiyan Ji (Author), Panpan Lu (Author), Baochi Liu (Author), Xiying Qu (Author), Yanan Wang (Author), Zhengtao Jiang (Author), Xinyi Yang (Author), Yangcheng Zhong (Author), He Yang (Author), Hanyu Pan (Author), Lin Zhao (Author), Jianqing Xu (Author), Hongzhou Lu (Author), Huanzhang Zhu (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Highly active anti-retroviral therapy (HAART) cannot clear infected cells harboring HIV-1 proviral DNA from HIV-1-infected patients. We previously demonstrated that zinc-finger nucleases (ZFNs) can specifically and efficiently excise HIV-1 proviral DNA from latently infected human T cells by targeti...