Measurement of 17-Hydroxyprogesterone by LCMSMS Improves Newborn Screening for CAH Due to 21-Hydroxylase Deficiency in New Zealand

• Hoofdauteurs: Mark R de Hora (Auteur), Natasha L Heather (Auteur), Tejal Patel (Auteur), Lauren G Bresnahan (Auteur), Dianne Webster (Auteur), Paul L Hofman (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The positive predictive value of newborn screening for congenital adrenal hyperplasia due to 21-hydroxylase deficiency was <2% in New Zealand. This is despite a bloodspot second-tier immunoassay method for 17-hydroxyprogesterone measurement with an additional solvent extract step to reduce the nu...