Population Pharmacokinetic Modeling of a Desmopressin Oral Lyophilisate in Growing Piglets as a Model for the Pediatric Population

• Main Authors: Elke Gasthuys (Author), An Vermeulen (Author), Siska Croubels (Author), Joske Millecam (Author), Stijn Schauvliege (Author), Thomas van Bergen (Author), Pauline De Bruyne (Author), Johan Vande Walle (Author), Mathias Devreese (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Desmopressin is used to treat primary nocturnal enuresis in children. Over the years, various formulations of desmopressin were commercialized of which the sublingual melt tablet is preferred in the pediatric population, despite the lack of full PK studies in this population. A full PK study was per...