Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

• Prif Awduron: Fatou K. Ndiaye (Awdur), Ana Ortalli (Awdur), Mickaël Canouil (Awdur), Marlène Huyvaert (Awdur), Clara Salazar-Cardozo (Awdur), Cécile Lecoeur (Awdur), Marie Verbanck (Awdur), Valérie Pawlowski (Awdur), Raphaël Boutry (Awdur), Emmanuelle Durand (Awdur), Iandry Rabearivelo (Awdur), Olivier Sand (Awdur), Lorella Marselli (Awdur), Julie Kerr-Conte (Awdur), Vikash Chandra (Awdur), Raphaël Scharfmann (Awdur), Odile Poulain-Godefroy (Awdur), Piero Marchetti (Awdur), François Pattou (Awdur), Amar Abderrahmani (Awdur), Philippe Froguel (Awdur), Amélie Bonnefond (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Elsevier, 2017-06-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Objectives: Genome-wide association studies (GWAS) have identified >100 loci independently contributing to type 2 diabetes (T2D) risk. However, translational implications for precision medicine and for the development of novel treatments have been disappointing, due to poor knowledge of how these...