Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion

• Main Authors: Fatou K. Ndiaye (Author), Ana Ortalli (Author), Mickaël Canouil (Author), Marlène Huyvaert (Author), Clara Salazar-Cardozo (Author), Cécile Lecoeur (Author), Marie Verbanck (Author), Valérie Pawlowski (Author), Raphaël Boutry (Author), Emmanuelle Durand (Author), Iandry Rabearivelo (Author), Olivier Sand (Author), Lorella Marselli (Author), Julie Kerr-Conte (Author), Vikash Chandra (Author), Raphaël Scharfmann (Author), Odile Poulain-Godefroy (Author), Piero Marchetti (Author), François Pattou (Author), Amar Abderrahmani (Author), Philippe Froguel (Author), Amélie Bonnefond (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Genome-wide association studies (GWAS) have identified >100 loci independently contributing to type 2 diabetes (T2D) risk. However, translational implications for precision medicine and for the development of novel treatments have been disappointing, due to poor knowledge of how these...