Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

• मुख्य लेखकों: Tamara Heintze (लेखक), Denise Wilhelm (लेखक), Thierry Schmidlin (लेखक), Ute Hofmann (लेखक), Ulrich M. Zanger (लेखक), Matthias Schwab (लेखक), Kathrin Klein (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

NADPH:cytochrome P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450 (CYP) enzymes involved in the biosynthesis of endogenous substances like bile acids and other steroids as well as in the oxidative metabolism of xenobiotics. P450 oxidoreductase also supports oth...