Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence

• Main Authors: Emadeldin Hassanin (Author), Isabel Spier (Author), Dheeraj R. Bobbili (Author), Rana Aldisi (Author), Hannah Klinkhammer (Author), Friederike David (Author), Nuria Dueñas (Author), Robert Hüneburg (Author), Claudia Perne (Author), Joan Brunet (Author), Gabriel Capella (Author), Markus M. Nöthen (Author), Andreas J. Forstner (Author), Andreas Mayr (Author), Peter Krawitz (Author), Patrick May (Author), Stefan Aretz (Author), Carlo Maj (Author)
• Format: Book
• Published: BMC, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background and aims Summarised in polygenic risk scores (PRS), the effect of common, low penetrant genetic variants associated with colorectal cancer (CRC), can be used for risk stratification. Methods To assess the combined impact of the PRS and other main factors on CRC risk, 163,516 indi...