Streptozotocin-Induced Hyperglycemia Affects the Pharmacokinetics of Koumine and its Anti-Allodynic Action in a Rat Model of Diabetic Neuropathic Pain

• Main Authors: Li-Xiang Ye (Author), Hui-Hui Huang (Author), Shui-Hua Zhang (Author), Jing-Shan Lu (Author), Da-Xuan Cao (Author), Dan-Dan Wu (Author), Pei-Wang Chi (Author), Long-Hui Hong (Author), Min-Xia Wu (Author), Ying Xu (Author), Chang-Xi Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Koumine (KM), the most abundant alkaloid in Gelsemium elegans, has anti-neuropathic, anti-inflammatory, and analgesic activities; thus, it has the potential to be developed as a broad-spectrum analgesic drug. However, factors determining the relationship between analgesic efficacy and the correspond...