Hybrid Silica-Coated PLGA Nanoparticles for Enhanced Enzyme-Based Therapeutics

• Main Authors: Kyle T. Gustafson (Author), Negin Mokhtari (Author), Elise C. Manalo (Author), Jose Montoya Mira (Author), Austin Gower (Author), Ya-San Yeh (Author), Mukanth Vaidyanathan (Author), Sadik C. Esener (Author), Jared M. Fischer (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Some cancer cells rely heavily on non-essential biomolecules for survival, growth, and proliferation. Enzyme based therapeutics can eliminate these biomolecules, thus specifically targeting neoplastic cells; however, enzyme therapeutics are susceptible to immune clearance, exhibit short half-lives,...