Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry

• Main Authors: Marta Menicatti (Author), Marco Pallecchi (Author), Silvia Bua (Author), Daniela Vullo (Author), Lorenzo Di Cesare Mannelli (Author), Carla Ghelardini (Author), Fabrizio Carta (Author), Claudiu T. Supuran (Author), Gianluca Bartolucci (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a faulty autoimmune response. Recently, it was reported that some human carbonic anhydrases (CAs) isoforms are overexpressed in inflamed synovium of RA patients. New CA inhibitors (CAIs) incorporating CA-binding moiety and the cyc...