Resolution of co-eluting isomers of anti-inflammatory drugs conjugated to carbonic anhydrase inhibitors from plasma in liquid chromatography by energy-resolved tandem mass spectrometry

• 主要な著者: Marta Menicatti (著者), Marco Pallecchi (著者), Silvia Bua (著者), Daniela Vullo (著者), Lorenzo Di Cesare Mannelli (著者), Carla Ghelardini (著者), Fabrizio Carta (著者), Claudiu T. Supuran (著者), Gianluca Bartolucci (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by a faulty autoimmune response. Recently, it was reported that some human carbonic anhydrases (CAs) isoforms are overexpressed in inflamed synovium of RA patients. New CA inhibitors (CAIs) incorporating CA-binding moiety and the cyc...